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What are we actually measuring the solubility
of?
Dr. Jonathan Burley MChem DPhil, Lecturer in
Pharmaceutical Nanotechnology, Laboratory of Biophysics and Surface Analysis,
Room D04, Boots Science Building, University of Nottingham, University Park
Nottingham, NG7 2RD
Solubility measurements are becoming increasing accurate and reliable, but a
key aspect of understanding drug dissolution profiles is to have a sound
knowledge of the material we are measuring the solubility of. This is especially
important as many pharmaceutical compounds can form hydrates, exhibit
polymorphism etc. This talk will cover determining what we are measuring the
solubility of through the use of X-ray powder diffraction. Examples will include
pattern matching, quantitative analysis of mixtures and ab-initio structure
solution to determine the crystal structures of new, previously unknown
materials uncovered in solubility measurements.
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